Today, knowledge of ergonomics is viewed as an effective factor of individual and organizational productivity and performance. The purpose of the present research is to determine the relationship between knowledge of ergonomics and effective factors of labor productivity in Pars Special Economic Energy Zone, site 2, and Iranian PetroPaydar Company. This is a correlation study. Research statistical population included employees of the two aforementioned (N=244). 96 individuals were selected as research sample through using simple random sampling method. Data were collected through using a five-point Likert scale (from extremely low to extremely high) questionnaire consisting of three demographic, ergonomic, and productivity divisions. Data of research samples were gathered using self-response method and analyzed through descriptive statistical indicators and Chi- square test. Research findings show that there is a significant relationship between ergonomics and productivity; further, staffs’ highest mean scores were assigned to the clarity and role recognition (73.73), and ability (59.54) components. According to the obtained results, it is concluded that increasing labor productivity requires higher knowledge of ergonomics.